Fourteen healthy children (13.8±2.2 years, range 10 to 16; M:F=5:9) received 30 Hz intermittent theta burst transcranial magnetic stimulation (iTBS) with a stimulation intensity of 70% of resting motor threshold (RMT) with a total of 300 (iTBS300) pulses. All volunteers were free of neurologic, psychiatric and serious medical illnesses, not taking any neuropsychiatric medications, and did not have any contraindications to Transcranial Magnetic Stimulation. Changes in the mean amplitudes of motor-evoked potentials from baseline following iTBS were expressed as a ratio (...) and assessed from 1 to 10 minutes (BLOCK1) and 1 to 30 minutes (BLOCK2) using repeated-measures analysis of variance. All 14 subjects completed iTBS300 over the dominant primary motor cortex (M1) without any clinically reported adverse events. ITBS300 produced significant M1 facilitation (F5,65=3.165, p=0.01) at BLOCK1 and trend level M1 facilitation at BLOCK2 (F10,129=1.69, p=0.089). Although iTBS300 (stimulation duration of 92 seconds at 70% RMT) delivered over M1 in typically developed children was well-tolerated and produced on average significant facilitatory changes in cortical excitability, the post-iTBS300 neurophysiologic response was variable in our small sample. ITBS300-induced changes may represent a potential neuroplastic biomarker in healthy children and those with neuro-genetic or neuro-psychiatric disorders. However, a larger sample size is needed to address safety and concerns of response variability. (shrink)

After hearing Donald Trump's acceptance speech at the Republican National Convention held in Cleveland, Ohio, Newt Gingrich was interviewed live on CNN about the menacing tone of the address. Gingrich not only defended Trump's nearly apocalyptic vision of America if he was not elected, the former Speaker of the House swiped aside the clear data that indicated that the criminalized landscapes portrayed in Trump's speech might just be the work of a frenzied and fearful imagination rather than based in (...) fact. "'People feel more threatened,'" Gingrich insisted. "'As a political candidate, I'll go with what people feel '". Commenting in Forbes shortly thereafter, Ethan Siegel, a scientist and science... (shrink)

Germ-line therapy has long been regarded with great caution both by scientists and by ethicists. Even those who do not reject germ-line therapy in principle have tended to reject it in practice as carrying unacceptable risks in our current state of knowledge. For this reason, a recent paper by Rubenstein, Thomasma, Shon, and Zinaman is unusual in putting forward a serious proposal for the use of germ-line therapy in the foreseeable future.

Technology is fundamental to and embedded in the way practice is conceptualized and institutionalized in social service work. Many scholars assume and expect that good practices of care are achieved with the correct application of theory produced by rigorous scientific research. However, there are significant critiques of this viewpoint. We examine the work of Donald Schön and Martin Heidegger and agree with these authors' suggestions that technical rationality and modern technology are not the way to achieve good practice in (...) the human services. At the same time, we are not convinced that the alternatives offered by Schön and Heidegger provide what good practice requires. We draw on Aristotle's account of the intellectual virtues and make the case for phronesis and praxis as other possibilities for inspiring new kinds of social welfare practice in the twenty-first century. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

Greg Ray (2014) believes he has discovered a crucial oversight in Donald Davidson’s semantic programme, recognition of which paves the way for a novel approach to Davidsonian semantics. We disagree: Ray’s novel approach involves a tacit appeal to pre-existing semantic knowledge which vitiates its interest as a development of the Davidsonian programme.

This book marks the first publication of celebrated philosopher Donald Davidson's 1970 Locke Lectures. In detailing his work on the theory of meaning, the role of a truth theory, the ontological commitments of a truth theory, and the notion of logical form, these lectures offer a rare insight into Davidson's thought at a key moment in his career.

When I was a student in the mid-1980s, Donald Davidson loomed larger over the philosophical scene than any other living thinker. His writings figured prominentl.

This article concerns primarily the concepts of God in process theism, especially as they appear in the later writings of A. N. Whitehead and in the works of Charles Hartshorne. The article concludes with a brief discussion of arguments for God's existence in process thought and a note on the historical influences on, and anticipations of, process theism.

Part I: Inductivism and its Critics:. 1. Some Historical Background: Inductivism, Russell and the Cambridge School, the Vienna Circle and Popper. 2. Popper’s Critique of Inductivism. 3. Duhem’s Critique of Inductivism. Part II: Conventionalism and the Duhem-Quine Thesis:. 4. Poincare’s Conventionalism of 1902. 5. The Duhem Thesis and the Quine Thesis. Part III: The Nature of Observation:. 6. Observation Statements: the Views of Carnap, Neurath, Popper and Duhem. 7. Observation Statements: Some Psychological Findings. Part IV: The Demarcation between Science and (...) Metaphysics:. 8. Is Metaphysics Meaningless? Wittgenstein, the Vienna Circle and Popper’s Critique. 9. Metaphysics in relation to Science: the Views of Popper, Duhem and Quine. 10. Falsification in the light of the Duhem-Quine Thesis. (shrink)

Ralph Waldo Emerson is one of the most significant figures in nineteenth-century American literature and culture-indeed, this collection argues, in the history of philosophy. The Other Emerson is a thorough reassessment of the philosophical underpinnings, theoretical innovations, and ethical and political implications of the prose writings of one of America's most enduring thinkers. Considering Emerson first and foremost as a daring and original thinker, _The Other Emerson_ focuses on three Emersonian subjects-subjectivity, the political, and the nature of philosophy-and range in (...) topic from Emerson's relationships to slavery and mourning to his place in the development of Romanticism as reread by contemporary systems theory. It is Emerson's appreciation of truth's instability that link him to the European philosophical tradition. Contributors: Eduardo Cadava, Princeton U; Sharon Cameron, Johns Hopkins U; Russell B. Goodman, U of New Mexico; Paul Grimstad, Yale U; Eric Keenaghan, U at Albany, SUNY; Gregg Lambert, Syracuse U; Sandra Laugier, Université de Picardie Jules Verne; Donald Pease, Dartmouth College. (shrink)

Technical results about the time dependence of eigenvectors of reduced density operators are considered, and the relevance of these results is discussed for modal interpretations of quantum mechanics which take the corresponding eigenprojections to represent definite properties. Continuous eigenvectors can be found if degeneracies are avoided. We show that, in finite dimensions, the space of degenerate operators has co-dimension 3 in the space of all reduced operators, suggesting that continuous eigenvectors almost surely exist. In any dimension, even when degeneracies are (...) hit, we find conditions under which a theorem due to Rellich can provide continuous eigenvectors. We use this result to formulate an extended version of the modal interpretation. We also discuss eigenvector instability which we argue poses a serious problem for the modal interpretation, even in our extended version. Many examples are given to illustrate the mathematics. (shrink)

This exploration of how people came to appreciate numbers traces the ways in which early humans gradually evolved methods for recording numerical data and ...

This paper suggests a new principle for confirmation theory which is called the principle of explanatory surplus. This principle is shown to be non-Bayesian in character, and to lead to a treatment of simplicity in science. Two cases of the principle of explanatory surplus are considered. The first (number of parameters) is illustrated by curve-fitting examples, while the second (number of theoretical assumptions) is illustrated by the examples of Newton's Laws and Adler's Theory of the Inferiority Complex.

Is it possible to donate unpaired vital organs, foreseeing but not intending one’s own death? We argue that this is indeed psychologically possible, and thus far agree with Charles Camosy and Joseph Vukov in their recent paper on “double effect donation.” Where we disagree with these authors is that we see double-effect donation not as a morally praiseworthy act akin to mar- tyrdom but as a morally impermissible act that necessarily disrespects human bodily integrity. Respect for bodily integrity goes beyond (...) avoiding the aim to kill; not all side effects of deliberate bodily interventions can be outweighed by intended benefits for another even if the subject fully consents. It is not any necessary intention to kill or harm another or oneself that makes lethal donation/harvesting illicit but the more immediate intention to accept or perform surgery on an (innocent) person combined with the foresight of lethal harm and no health-related good for him or her. Double-effect donation falls foul of the first condition of double-effect reasoning in that the immediate act is wrong in itself. We argue further that the wider effects of such don- ation would be socially disastrous and corrupting of the medical profession: doctors should retain a sense of nonnegotiable respect for bodily integrity even when they intervene on willing subjects for the benefit of others. (shrink)

Carruthers argues that an integrated faculty of metarepresentation evolved for mindreading and was later exapted for metacognition. A more consistent application of his approach would regard metarepresentation in mindreading with the same skeptical rigor, concluding that the “faculty” may have been entirely exapted. Given this result, the usefulness of Carruthers’ line-drawing exercise is called into question.

Oxford Studies in Early Modern Philosophy is an annual series, presenting a selection of the best current work in the history of early modern philosophy. It focuses on the seventeenth and eighteenth centuries—the extraordinary period of intellectual flourishing that begins, roughly, with Descartes and his contemporaries and ends with Kant. It also publishes work on thinkers or movements outside of that framework, provided they are important in illuminating early modern thought. The core of the subject matter is philosophy and its (...) history. But the volume’s chapters reflect the fact that philosophy in the early modern period was much broader in scope than it is currently taken to be and included a great deal of what now belongs to the natural sciences. Furthermore, philosophy in the period was closely connected with other disciplines, such as theology, law, and medicine, and with larger questions of social, political, and religious history. Volume XI includes chapters dedicated to a wide set of topics in the philosophies of René Descartes, Johann Clauberg, Louis de La Forge, Benedict Spinoza, Margaret Cavendish, Henry More, Ralph Cudworth, Mary Astell, and Damaris Masham. (shrink)